The demand of pharmaceutical freeze dryer is expanding, but these problems are worthy of attention
Freeze drying technology is a new type of processing technology, which has the advantages of low temperature drying, less destruction of effective components, loose and easy to dissolve and absorb, drying and sterilization at the same time. Compared with the ordinary drying technology, it is dried at low temperature, and the loss of some volatile components in the material is very small. It can maintain the original properties, so that the dried product can be preserved for a long time without deterioration.
In recent years, with the rapid development of the pharmaceutical industry, the demand for pharmaceutical freeze dryer is also expanding. It is pointed out in the industry that the demand of vacuum freeze dryer equipment with larger specifications and functional combination (such as granulation drying, drying filtration) is increasing. In the face of the new market demand and new requirements, domestic freeze dryer enterprises are also speeding up the research of vacuum drying technology, creating more new type of refrigerator equipment, meeting the requirements of users to reduce energy consumption, reduce pollution, reduce enterprise costs, and bring more benefits and value to the society.
It is worth noting that although the technology of freeze dryer has made continuous progress, in order to ensure the stable operation of the equipment and prolong its service life, users need to pay attention to the operation, maintenance and other issues related to the freezing equipment in the process of operating the equipment.
For example, before using the freeze dryer equipment, users need to understand the precautions during the production of the equipment, including ensuring that the freeze dryer operates in a stable environment to avoid the equipment in a dangerous or unbalanced environment; strictly follow the steps to operate the freeze dryer; avoid contacting with corrosive substances to prevent the mechanical performance of the freeze-drying mechanism from being damaged, thus leading to machine failure; in addition, the operator should Also need to pay attention to prevent limb frostbite, in the operation to do the corresponding protective measures, to achieve safe production.
Maintenance is also the key work to ensure the long-term stable operation of the freeze dryer. For example, for the maintenance of the equipment in operation, it is necessary to check whether there is leakage of water, oil and gas; whether the cooling tower cooling effect is good; clean the cleanable parts of the machine before the shift handover; record the suction, exhaust and pressure of each level regularly, and fill in the record according to the content of the record sheet; check the air inlet temperature of the cold dryer; check the automatic blowdown Whether the manual blowdown is normal, whether the operation of the cold dryer is normal, if any blockage is found, it needs to be removed and cleaned in time; check whether the water pressure flow of the cooling water system is sufficient; clean the condenser every month.
In addition, the wearing parts should be replaced according to their service life: under normal circumstances, the replacement principle is: the service life of all levels of filters (3 μ m, 1 μ m, 0.01 μ m) is 6000 hours for imported ones and 4000 hours for domestic ones. It is worth noting that if the equipment is shut down for a long time, attention should be paid to the sewage discharge to drain all the water. And need to arrange personnel to do maintenance records, including time, personnel, maintenance or fault content, replacement parts list and other elements.
At the same time, it is also necessary for operators to understand the common fault causes and solutions of the equipment, so as to avoid being helpless when the equipment fails. For example, the vacuum degree of vacuum freeze dryer is often low, which may be caused by too high pump temperature, pump oil problem, air leakage of pump itself, blockage of air inlet filter screen, etc. the solutions include reassembly after repair; refueling; oil changing; checking the oil inlet of oil circuit and oil valve; replacing sealing ring or valve piece according to specific conditions; removing and cleaning, etc.
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