January 6, 2022
Q1：Does the dry granulator also need a binder?
A：The dry granulator does not require a binder during the granulation process.
Q2：What are the wearing parts of the dry granulator?
A：Depending on the model, usually O-rings, PTFE scrapers, etc.
Q3：Can the dry granulator complete drying and granulation?
A：The dry granulator is to directly compress the dry powder into granules without drying function.
Q4：What is the largest particle diameter that can be achieved with a dry granulator for dry powder?
A：It can be up to 0.3mm, and it can also be 0.5mm, but it is not guaranteed. If it is bigger, wet materials must be used.
Q5：Is dry granulation easier than wet granulation? Pressing directly after granulation without drying?
A：Yes.Dry granulation can directly make the powder into granules without adding any additives, making it easier to control the production process and material composition.
Q6：Under what circumstances need dry granulation and wet granulation?
A：Products that are sensitive to temperature and humidity are suitable for dry granulation. Dry granulation is suitable for granulating raw materials that cannot be added with a binder, and it is also suitable for powders with low humidity. However, wet granulation can obtain particles with better fluidity and graininess. Dry granulation is not as stable as wet granulation. Formula granules are generally used in the dry process.
Q7：The temperature and speed of the wet mixing granulator are all controlled by the touch screen and PLC?
A：The temperature is controlled by the jacket for cooling, and all others are controlled by the touch screen.
Q8：Is it necessary to add swing granulation after wet mixing granulation?
A：Some Chinese medicine ingredients are very viscous, and the auxiliary materials containing sugars are easy to become "lumps" when granulating, so rocking granulation must be added.
Q9：Do we need cone mill after wet granulation?
A：Yes, the particles after wet granulation need to be cone milled
Q10：Why is wet granulation divided into high position and low position? Is it the height limit of the site? What are the advantages and disadvantages of high and low positions?
A：This mainly depends on the size of the workshop and the production process. high position wet granulation is more suitable for connection.
Q11：What are the feeding methods for granulation?
A：The granulation feeding method is divided into vertical and horizontal feeding.
Q12：How long does it take for a batch of granulator to mix?
A：Dry granulation is continuous and there is no concept of batch. The wet mixing granulator usually takes 15-20 minutes.
Q13：Does it need to be dried after granulation?
A：Yes. Because the binder or water is added during the previous mixing, it needs to be dried after granulation, which can be dried in a fluidized bed or in an oven.
Q14：How many kilograms of materials are suitable for in-wall solid preparations
Q15：Cocoa granulator, two methods:
A：1. Adopt wet mixing granulator, swing granulation and fluidized bed drying to make the granules uniform and full.
2. Adopting one-step granulator, saving cost and floor space, but the granules are loose and different in size.
3. The raw material must be powder
Q16：Closed granulation line
A：It is divided into wall type and separate online type.
Wall type: Only the main unit is indoors, and the wall of the main unit is stainless steel, which is more hygienic and tidy, and more convenient to use. However, there are certain requirements for the height of the plant, and it is necessary to know its output and the height of the plant.
Separate online type: It is connected with a vacuum system. The whole machine of the shear mixer is in the workshop, and it is not as easy to clean as the wall. There are no special requirements for the plant.
Q17：How to control the size of the particles?
A：Change the sieve of the granulator.
Q18：What are the requirements for the plant in the closed granulation line?
A：There are requirements for the layout and height of the plant.
Q19：What is the difference between the equipment used for closed granulation line and split granulation line?
A：The structure is different. The closed granulation line can be better used for the production of anti-cancer drugs because of better CIP and isolation.
Q20：Can the granulating function of the fluidized bed replace the swing granulator?
A：No, this is a completely different process, and the products made are also different.
Q21：Under what circumstances is it recommended to use a swing granulator?
A：1. Use cone mill after wet mixing and granulation
2. Granulation after groove type mixing
3. Tablet recycling and grinding.
Economical granulation method.
Q22：How to control the powder mesh of the universal pulverizer?
A：80-120 mesh, according to the sieve aperture.
Q23：Under what circumstances does the shredder need a cloth bag?
A：When there is a lot of dust.
Q24：Production process of sulfide fertilizer
A：Spray drying (liquid into powder)——wet mixing——extrusion granulation——fluidized bed drying
Q25：What granulation is used for sulfide fertilizer
A：There are 3 methods of granulation:
1. Swing granulation: the particles are looser, the size of the particles is uniform, and the price is cheap.
2. Rotary granulation/centrifugal granulation: the same as swing granulation, the price is also similar
3. Screw extrusion granulation: the granules are compact and cylindrical, and may also have a strip shape, which is not very uniform, and the production unit is larger.
Q26：Can the spheronization machine control the diameter of the pill?
A：Yes, the spheronizer can control the diameter of the pellets by controlling the diameter of the extrusion.